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They are primarily generated through enzymatic reactions involving NADPH oxidases (NOXs), cytochrome P450 reductase (POR), and NADH-cytochrome b5 reductase (CYB5R1), with the mitochondrial electron transport chain (mETC) serving as another significant source (Yan et al., 2021)
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All mice were screened for rd1 and rd8 mutations and were negative for these mutations
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